Five people were taken to the hospital after a two-car accident on Route 9 in Southboro Sunday morning.
Emergency crews found one person trapped and injured in a pickup truck on its side off the side of the road.
The other vehicle had four occupants, one of whom was unresponsive.
Four of the injured were taken to UMass Worcester and the other was taken to Metro West Framingham.
Route 9 was closed until 7 a.m. Sunday for crews to investigate the accident.